Fig. 7: Orientation-selective responses in the LGN are largely independent of DSRGC and SAC activities. | Nature Communications

Fig. 7: Orientation-selective responses in the LGN are largely independent of DSRGC and SAC activities.

From: Differential topographic organization and retinal inheritance of direction and orientation selectivity in the visual thalamus

Fig. 7: Orientation-selective responses in the LGN are largely independent of DSRGC and SAC activities.

a Hypothesized model of creating AS responses by convergence of two DS inputs. b Schematic of experimental method. DT-injected mice were either used for MEA recording of the retina (c-d) or in vivo Neuropixels recordings of the LGN (e-h). c Polar plots of example OSRGCs from a wild-type control retina (left) and a DT retina (right). d Proportion of OSRGCs in wild-type control and DT conditions. N = 25/8 retina recordings for WT Control and DT conditions, respectively. Bar height represents weighted mean ± SEM. p-value according to bootstrapping analysis (one-sided; p = 0.41). e Example of OS units from all four LGN subregions. Notation as in Fig. 5a. f Percentage of OS units in control and DT conditions. Notation as in Fig. 4e. Number of recordings (N) and number of OS units out of total units are indicated below each bar. Bar height represents weighted mean ± SEM. p-values according to bootstrapping analysis (one-sided). g Polar histogram showing the preferred orientations of all OS cells recorded in DT conditions in the dLGN-shell, core, IGL and vLGN. h Cumulative distribution of tuning width (in degrees) for all OS units recorded in the control and DT condition per area. p-values according to two-sided Wilcoxon rank-sum test. D dorsal, T temporal, N nasal, V ventral, P posterior, A anterior, S superior, I inferior, sp spikes. ****p < 0.0001. n.s.: not significant.

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