Fig. 1: ZnFs interact with LC domains.
From: Zinc finger domains bind low-complexity domain polymers
a Venn diagram showing gene overlap in two comparisons, RNA-seq data of motor neurons derived from FUS mutant hiPSCs (FUS mutant) and ChIP-seq data of CoCl2-treated Human aortic endothelial cell (HAEC_CoCl2). b Percentages of genes encoding zinc binding and ZnF domains in the three datasets of FUS mutant, HAEC_CoCl2, and human proteome. c Binding assays of GFP fusion KLF4 fragments to hydrogels derived from the mCherry fusion hnRNPA2 LC domain (mCh:A2-LC). d Binding assays of various GFP fusion ZnF (GFP:ZEB1 ZnF5-7, ZEB2 ZnF6-8, and ZNF512B ZnF3-5) to mCh:A2-LC. e Binding assays of GFP fusion ZEB2 ZnF6-8 (GFP:ZEB2 ZnF6-8) to various mCherry fusion LC domains (mCh:A2-LC, mCh:FUS-LC, and mCh:TDP43-LC). f Binding assays of GFP fusion ZEB2 fragments to mCh:A2-LC hydrogels.
