Fig. 1: Transcriptomic profiling of macrophages harboring redox diverse Mtb.
From: Bioenergetic reprogramming of macrophages reduces drug tolerance in Mycobacterium tuberculosis
A Schematic showing flow sorting–coupled RNA seq of macrophage subpopulations: uninfected (green), bystanders (gray), macrophages harboring EMSH-oxidized (yellow, here on labeled as ‘oxidized’) or EMSH-reduced (blue, here on labeled as ‘reduced’) Mtb; B Principal component analysis (PCA) plot comparing infected and uninfected macrophages; C PCA plot showing the subpopulations within the infected macrophages: ‘bystanders’, ‘oxidized’, ‘reduced’; D Heat map of genes differentially expressed between the subpopulations; genes clustered according to their involvement in pathways: E Oxidative phosphorylation; F NRF2 regulon; G Hippo signaling. Heatmaps are generated from three independent experiments with base mean >10, FDR < 0.1, and log2FC > 0.6. Figure 1A: Created in BioRender. Yadav, V. (2025) https://BioRender.com/6x5yph4. Source data are provided as a Source Data file.
