Fig. 5: CTSL-BNIP3 network dual functions in tumorigenesis and muscle wasting. | Nature Communications

Fig. 5: CTSL-BNIP3 network dual functions in tumorigenesis and muscle wasting.

From: Cathepsin L as a dual-target to mitigate muscle wasting while enhancing anti-tumor efficacy of anti-PD-L1

Fig. 5: CTSL-BNIP3 network dual functions in tumorigenesis and muscle wasting.

A Scatter plots of genes ranked by Pearson’s correlation with Ctsl expression across lung tumor and skeletal muscle (TB versus CON). B Comparative ranking of these correlation coefficients in lung tumor versus muscle for Ctsl’s direct neighbors in PPI network (as shown in Fig. 3E). C Correlation of Ctsl versus Bnip3 expression in lung tumor and muscle (log2 TPM + 1). D Three-way Venn diagram of Ctsl’s direct neighbors that are upregulated in lung tumor, upregulated in muscle (TB versus CON), and downregulated in muscle (αCD8a versus IgG). Subnetwork of Ctsl-Bnip3 neighbors upregulated in tumors (E, TB versus CON; node color represents log2 FC). Bar plot (F) of KEGG pathways enriched among genes (adjusted p-value < 0.05). Subnetwork of Ctsl-Bnip3 neighbors (G) upregulated in muscle (left in the box: TB versus CON) and downregulated in muscle (right in the box: αCD8a versus IgG group). Node color indicates log2 FC. Bar plots (H) of KEGG pathways enriched among genes (adjusted p-value < 0.05). For C, two-sided t-test for Pearson correlation; for F and H, hypergeometric test with Benjamini–Hochberg correction. Source data are provided as a Source Data file.

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