Fig. 5: Plasmid evolution over time within clonal transmission clusters and within the same patient. | Nature Communications

Fig. 5: Plasmid evolution over time within clonal transmission clusters and within the same patient.

From: Plasmid dynamics driving carbapenemase gene dissemination in healthcare environments: a nationwide analysis of closed Enterobacterales genomes

Fig. 5

Plasmid profiles of A blaKPC-2-positive and B blaNDM-1-positive clonal transmission clusters. Clonal transmission clusters comprising three or more isolates are shown. Each column represents a clonal transmission cluster comprising index isolates that met pairwise clonal linkage criteria with at least one earlier index isolate from another patient. An index isolate was defined as the first-detected isolate carrying a unique carbapenemase gene in a patient during the study period. For each cluster, carbapenemase plasmid genes are arranged along the y-axis and isolates are arranged along the x-axis according to date of culture, from earliest to latest (left to right). Heat map indicates gene presence (colored) or absence (greyed). The number of isolates per clonal transmission cluster as well as number of days between the earliest and latest isolate detected are shown.

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