Table 1 Proportions of DIPs in the three commercially sourced monovalent LAIV prototypes and H3N2 LAIV preparations with varying proportions of DIPs
Strain designation | STV (EID50/mL) | HA (HAU/100 µL) | Total particles /mLa | Proportion of STV (%)a | Proportion of DIPs (%)a | Ratio of STV to HAb |
|---|---|---|---|---|---|---|
Commercially sourced LAIV prototypes | ||||||
A/17/Hong Kong/2014/8296 (H3N2) | 5.0 × 1010 | 219 | 1.0 × 1013 | 0.5 | 99.5 | 9536.7 |
A/New York/61/2015-CDC-LV16A (H1N1)pmd09 | 1.9 × 1011 | 217 | 2.6 × 1012 | 7.3 | 92.7 | 144,958.5 |
B/56/Brisbane/60/08 (Victoria lineage) | 6.7 × 109 | 214 | 3.3 × 1011 | 2.0 | 98.0 | 40,893.6 |
H3N2 LAIV preparations (A/17/Hong Kong/2014/8296) with varying proportions of DIPs | ||||||
Low DIPs LAIV | 3.6 × 109 | 29 | 1.0 × 1010 | 36.0 | 64.0 | 703,125.0 |
Middle DIPs LAIV | 1.7 × 1010 | 213 | 1.6 × 1011 | 10.6 | 89.4 | 207,519.5 |
High DIPs LAIV | 1.3 × 1010 | 217 | 2.6 × 1012 | 0.5 | 99.5 | 9918.2 |
