Fig. 5: Change in KOOS scores from baseline to EoS among participants with low or high neutralization response. | Nature Communications

Fig. 5: Change in KOOS scores from baseline to EoS among participants with low or high neutralization response.

From: Safety and immunogenicity of PPV-06, an active anti-IL-6 immunotherapy targeting low-grade inflammation against knee osteoarthritis: a randomized, double-blind, placebo-controlled, clinical phase 1 study

Fig. 5

Participants from the 10 µg PPV‑06 and 50 µg PPV‑06 groups were pooled, and participants with IL-6 neutralizing capacity above the median (n = 9) were compared to those with IL-6 neutralizing capacity below the median (n = 8). The lines represent the mean ± SD. Mann-Whitney test (two-tailed p-value) was used to analyze the statistical difference between groups. Source data are provided as a Source Data file. ADL Activity of Daily Living, QoL Knee-related Quality of Life.

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