Fig. 1: The postnatal plKO cerebellum exhibits an inflammatory signature.
From: Microglia alter sex-specific cerebellar myelination following placental hormone loss
a IPA analysis of differentially expressed genes (DEGs) comparing genotype and sex across postnatal development. The pathways were ranked by greatest –log(p-value). A right-tailed Fisher’s Exact Test was used with a cutoff of p < 0.05 and a 30% log2-fold change. Among the top 20 brain-related pathways identified, there was a prominent pattern of inflammation-related pathways. P0 (red), P7 (green), P15 (blue), and P30 (purple). b Diagram highlighting common genes in the canonical pathways identified by IPA. c Number of inflammation-associated DEGs (p-value < 0.05 and a 30% log2-fold change; (GO:0006954, “inflammatory response”; release 2022-07-01)) in the CB across postnatal development. Males in blue, females in red. Source data are provided as a Source Data file.
