Fig. 3: Male and female plKO placenta and embryonic brain tissues show unique inflammatory signatures.
From: Microglia alter sex-specific cerebellar myelination following placental hormone loss
a–j Inflammatory cytokine levels in paired placenta and embryonic brain at E15.5 were measured by multiplex assays. Box plots are presented with the median, interquartile range (25th–75th percentiles), and whiskers extending to the minimum and maximum values. Statistical analysis was performed using two-way ANOVAs comparing sex and genotype for each tissue, followed by Sidak multiple comparisons tests. C Male (n = 5), plKO Male (n = 7); C Female (n = 8), plKO Female (n = 5). # p < 0.05 for sex by genotype effect. ‡p < 0.05, ‡‡p < 0.01 for overall genotype effect. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001 for genotype pairwise comparisons. Brain: IL-6: Genotype effect (p = 0.0050); C Female vs. plKO ( p= 0.0168). IP-10: Genotype effect (p = 0.0187). TNF-α: Sex and Genotype interaction effect ( p= 0.0218). IL-17: C Female vs. plKO (p = 0.0002). IL-7: C Female vs. plKO ( p= 0.0123). LIF: C Female vs. plKO (p = 0.0024). Eotaxin: C Female vs. plKO (P = 0.0092). MCP-1: Genotype effect (p = 0.0206). M-CSF: C Male vs. plKO (p = 0.0395). Placenta: IL-6: Sex vs. Genotype interaction (p = 0.0261); C Female vs. plKO (p = 0.0182). IL-5: Sex vs. Genotype interaction (p = 0.0185). Source data are provided as a Source Data file.
