Fig. 1: Poly(imidazolium ester)s: synthesis and interactions with bacteria. | Nature Communications

Fig. 1: Poly(imidazolium ester)s: synthesis and interactions with bacteria.

From: Poly(imidazolium ester) antibiotic forms intracellular polymer-nucleic acid biomolecular condensates and fight drug-resistant bacteria

Fig. 1: Poly(imidazolium ester)s: synthesis and interactions with bacteria.The alternative text for this image may have been generated using AI.

a Chemical synthesis; b, c bacterial resistance evolution to P8 and antibiotic controls; d–g P8’s membrane activity. a Chemical  syntheses of poly(imidazolium ester)s (PIEs) (P1-P15). b Bacterial resistance evolutions of P. aeruginosa PAO1 after 20-day daily serial passaging in the presence of P8 or the conventional antibiotics (ciprofloxacin (CIP) and gentamycin (GEN)). c Bacterial resistance evolution of E. coli ATCC 8739 after 20-day daily serial passaging in the presence of P8, CIP or GEN. d The relative PI fluorescence intensity (F.I.) of untreated (UNT), P8-treated and colistin-treated P. aeruginosa PAO1. The treatment concentration of P8 and colistin was 16 µg/mL. e Time-lapse confocal images of P. aeruginosa PAO1 treated with FITC-P8 (8 µg/mL) in the presence of PI. f Cryo-TEM images of P. aeruginosa PAO1 treated with P8 (16 µg/mL). g Cryo-TEM images of untreated P. aeruginosa PAO1.

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