Table 1 In vitro antimicrobial activity of PIEs

	MIC (µg/ml)^a							MIC_GM (µg/ml)^b	IC₅₀	SI^d
	S. aureus	E. faecium	E. Coli	P. aeruginosa	A. baumannii	K. pneumoniae	E. cloacae	MIC_GM (µg/ml)^b	(µg/ml)^c
P1	128	>128	>128	>512	64	128	128	>141.3	>1024	-
P2	32	32	64	32	16	32	64	35.3	>1024	>29
P3	32	64	128	128	32	64	64	64.0	>1024	>16
P4	16	32	32	32	16	32	64	29.0	498	17
P5	4	8	16	8	8	8	16	8.8	>1024	>116
P6	8	8	16	16	16	8	32	13.1	849	65
P7	8	16	32	16	16	16	32	17.7	125	7
P8	4	2	8	4	8	4	8	4.9	>1024	>208
P9	8	4	16	8	8	8	16	8.8	254	29
P10	8	16	16	16	16	16	32	16.0	>1024	>64
P11	4	4	8	8	8	8	8	6.6	>1024	>155
P12	4	4	8	8	8	8	16	7.2	862	120
P13	4	4	8	8	8	8	16	7.2	275	38
P14	4	2	8	4	8	4	8	4.9	175	36
P15	4	2	8	8	8	8	8	5.9	46	8

^aMIC as measured by the minimum concentration of polymers inhibiting bacterial growth by at least 90%.^b MIC_GM, the geometric mean of the minimum inhibitory concentrations (MICs) across all bacteria tested in the table. The gram-positive bacterial strains were S. aureus ATCC 29213, E. faecium ATCC 19434, and the gram-negative bacterial strains were K. pneumoniae ATCC 13883, A. baumannii ATCC 19606, P. aeruginosa PAO1, E. coli ATCC 8739 and E. cloacae ATCC 13047. ^cIC₅₀, the concentration required to reduce the viability of 3T3 fibroblast cells by 50%. ^dSI (Selectivity Index for bacteria over mammalian cells) calculated by IC₅₀/MIC_GM, reflecting the therapeutic window of PIEs.

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