Table 2 In vitro antimicrobial activity of P8 and commercial antibiotics against multidrug-resistant strains

From: Poly(imidazolium ester) antibiotic forms intracellular polymer-nucleic acid biomolecular condensates and fight drug-resistant bacteria

 

MIC (μg/mL)

P8

VAN

IMP

GEN

CIP

CST

S. aureus USA300 (MRSAa)

4

<1

<1

<1

<1

64

S. aureus USA300 (LAC)

4

<1

<1

<1

8

32

S. aureus BAA39 (MRSA)

4

1

<1

256

4

128

E. faecalis 583 (VREb)

4

64

<1

>512

<1

>512

E. coli 958

8

128

<1

<1

128

2

E. coli ATCC BAA 2774

8

512

4

32

128

4

P. aeruginosa PAER

4-8

>512

512

32

128

2

P. aeruginosa BAA-2797

4-8

>512

256

>512

16

4

A. baumannii AB-1

8

256

64

>512

32

2

A. baumannii BAA 2803

8

64

32

>512

>512

8

K. pneumoniae BAA2784

8

512

128

<1

128

>512

K. pneumoniae KPNR

4

512

4

<1

32

2

P. mirabilis

4

>512

4

<1

<1

>512

S. marcescens

1

512

<1

<1

<1

256

  1. aMRSA Methicillin-resistant S. aureus. bVRE vancomycin-resistant Enterococcus. VAN vancomycin, IMP imipenem, GEN gentamycin, CIP ciprofloxacin, CST colistin.
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