Fig. 3: Identified methylation profiles for individuals with SMARCA1 variants. | Nature Communications

Fig. 3: Identified methylation profiles for individuals with SMARCA1 variants.

From: Pathogenic variants in SMARCA1 cause an X-linked neurodevelopmental disorder modulated by NURF complex composition

Fig. 3: Identified methylation profiles for individuals with SMARCA1 variants.

Volcano plots (left) show the mean methylation difference of cases and controls plotted against the -log10(p) values and highlight the selected differential probes for the distinct profiles of A SMARCA1 cohort, B male individuals carrying SMARCA1 variants (SMARCA1-M), and C female individuals with SMARCA1 variants (SMARCA1-F). MDS plots (center) and heatmaps (right) with Euclidean clustering show clustering of cases (red for males, orange for females) and unaffected controls (blue). Columns of the heatmap correspond to the samples and rows correspond to the selected probes.

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