Fig. 8: Perivascular cells undergo mesenchymal-to-epithelial transition to provide progenitors for uterine re-epithelialization.

Cartoon model depicts how estrogen directs the activation of Nestin+ perivascular cells in the uterus through modulation of vascular-mesenchymal Notch signaling interactions, leading to perivascular cell mesenchymal-to-epithelial transition and incorporation into the uterine epithelium.