Fig. 1: Mice with Dnmt1 knockout specific to limb mesenchymal cells exhibit significant limb shortening. | Nature Communications

Fig. 1: Mice with Dnmt1 knockout specific to limb mesenchymal cells exhibit significant limb shortening.

From: Dnmt1 determines bone length by regulating energy metabolism of growth plate chondrocytes

Fig. 1: Mice with Dnmt1 knockout specific to limb mesenchymal cells exhibit significant limb shortening.

A Gene-level association of single-nucleotide polymorphisms in the DNMT1 gene locus obtained from the Musculoskeletal Knowledge Portal (MSK-KP). -log10(p) values from two-sided MAGMA gene analysis (FDR corrected). B Skeletal preparations (Alcian Blue/Alizarin Red) of neonatal Dnmt1flox (left) and Dnmt1ΔPrx1 (right) mice. C Higher magnification images of skeletal preparations of forelimbs (upper panels) and hindlimbs (lower panels). D Length of tibiae from 1-week-old Dnmt1flox (n = 7) and Dnmt1ΔPrx1(n = 7) mice. E µCT images of tibiae from 6-week-old Dnmt1flox and Dnmt1ΔPrx1 mice. F Length of tibiae from 6-week-old Dnmt1flox (n = 15) and Dnmt1ΔPrx1(n = 13) mice. B, C, E Representative data from at least three individual mice are shown. D, F Data are mean ± s.d. Significance of mean differences was assessed using unpaired two-sided t-tests. Source data are provided as a Source Data file.

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