Fig. 2: Accessible chromatin landscape during X. tropicalis ZGA.
From: CANTAC-seq analysis reveals E2f1 and Otx1 coordinate zygotic genome activation in Xenopus tropicalis
a A schematic view of the five developmental stages examined by CANTAC-seq. Embryos were collected at 3.5 hpf, 4 hpf, 5.5 hpf, 7 hpf, and 12 hpf to generate genome-wide chromatin accessibility profiles for stages 7, 8, and 9 (blastula), 10 (gastrula), and 13 (neurula), respectively. ZGA zygotic genome activation, MBT midblastula transition, hpf hours post-fertilization. b The bar plot illustrates the number of accessible chromatin regions detected at each of the five developmental stages during ZGA. c Heatmaps of chromatin accessibility for the five developmental stages, two biological replicates for each stage. d The bar plot illustrates the number of newly gained accessible regions at different genomic locations during ZGA. e Genome browser view of two representative genomic regions that lose (mir427 cluster, chr3: 146,260,000–146,294,000) or gain (sox17 cluster, chr6: 115,150,000–115,191,000) chromatin accessibility during ZGA. Source data are provided in the Source Data file.
