Fig. 2: Sankey diagram for longitudinal changes in Long COVID status over time, among participants prospectively followed from initial SARS-CoV-2 infection.

Participants in the analysis cohort are followed from their 3 month visit after first SARS-CoV-2 infection into the following categories: Long COVID (meeting LCRI threshold of 11), LC Unspecified (not meeting LCRI threshold of 11), and active reinfection (symptom survey completed within 30 days of a reported on-study reinfection). Between 6 and 15 months, participants not meeting the LCRI threshold of 11 are stratified further into those who had LC at a prior visit included in the diagram (“Unspec-Prior LC”) and those who did not (“Unspec-No Prior LC”). Participants may also be categorized as “Missed”, meaning they do not have symptom survey data at that visit (but may have symptom survey data at later visits). LC Long COVID, LCRI Long COVID Research index, Unspec unspecified.