Fig. 6: Inter-omics concordance of goal-directed subgroup identification.
From: Deriving consensus sepsis clusters via goal-directed subgroup identification in multi-omics study
a Matrix plot depicting pairwise correlations of ulinastatin (UTI) benefit scores across omics layers (transcriptome, proteome, metabolome, phenome). Correlations were calculated using Pearson correlation. Diagonal histograms show the distribution of omics-specific benefit scores. Correlation coefficients (Corr) and significance (***P < 0.001) are annotated. b Sankey diagram illustrating alignment of cluster memberships derived from UTI benefit scores across omics layers. Edge widths reflect the proportion of patients consistently stratified into the same subgroup. c Matrix plot of pairwise correlations for fluid resuscitation benefit scores across omics layers, with diagonal histograms showing score distributions. Correlations were calculated using Pearson correlation, which is a two-sided test. (***P < 0.001). d Sankey plot demonstrating cross-omics concordance of fluid strategy subgroups, with cluster transitions quantified by patient overlap. Corr Pearson’s correlation coefficient, UTI ulinastatin, the Chinese Multi-omics Advances In Sepsis (CMAISE) Consortium.
