Fig. 5: Working model for lipid-mediated substrate transport. | Nature Communications

Fig. 5: Working model for lipid-mediated substrate transport.

From: Drug-bound outward-facing conformation of a heterodimeric ABC exporter suggests a putative mechanism of drug translocation

Fig. 5

BmrCD is shown in a cartoon with helices represented by cylinders. Hoechsts, lipids: lipids POV23 in IF(2HT/2ATP) and POV15 in OF(2HT), and ATP/ADPVi are shown by ball-and-stick model. The rest of the lipids are shown in sticks. Mg2+ ions are shown in green ball. Red arrows indicate the conformational changes. Four steps of the transport cycle are indicated by circled numbers. The structure models are as follows: IF(1ATP), AlphaFold3 generated model (See details in “Methods”); IF(2ATP), PDB 8FPF; IF(1HT/2ATP), PDB 8SZC; IF(2HT/2ATP), BmrCD_IF2; OF(2HT), BmrCD_OF; OC, PDB 8T1P.

Back to article page