Fig. 5: Lipidomics and transcriptomics for Prdx1-KD cells and integrated analyses. | Nature Communications

Fig. 5: Lipidomics and transcriptomics for Prdx1-KD cells and integrated analyses.

From: PRDX1 promotes testosterone synthesis and attenuates aging via redox regulation of ATG4B to modulate lipophagy

Fig. 5

a OPLS-DA plot of lipidomics analyses with NC and KD TM3 cells (n = 6). b Heat map displaying the overall changes of lipid molecules in each group. c Volcano plot of lipid molecules with significant upregulation or downregulation. d Volcano plot of lipid superclass referred from altered molecules in (c). e Heat map displaying the overall differences in mRNA levels between NC and KD cells revealed by transcriptomics (n = 3). f Top KEGG pathways shared in lipidomics and transcriptomics. The pathways associated with autophagy and lipid metabolism were highlighted in red.

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