Table 3 Evaluation of drug efficacy using the ERS2 in a synechia patient

From: Microengineered patient-derived endometrium-on-a-chip for the evaluation of endometrial receptivity and personalised translational medicine

ERS2

Patient-derived EoC

Main-Criteria

Sub-Criteria

Full Points

Normal

Synechia

Non-treated

+CXCL12

+hCG

+VitD3

Endometrial Receptivity

Intensity of Integrin αvβ3

5

4

1

3

5

3

Intensity of Osteopontin

5

4

2

3

3

4

Blood vessel formation

Area of angiogenic sprout

5

3

1

5

1

4

Area of blood vessel

5

4

1

5

3

4

Total

20

15

5

16

12

15

ERS2

 

Receptive

Non-Receptive

Receptive

Receptive

Receptive

IVF-ET outcome prediction

 

Success

Fail

Success

Success

Success

Clinical pregnancy outcome

 

Success

N/A (On-hold with issues of collecting good embryos)

N/A

N/A

N/A