Fig. 4: Biolayer Interferometry (BLI) binding kinetics for PGT121 and VRC07 with different isotypes.
a Association and dissociation curves showing the interactions between HIV Env proteins and antibodies at three different antibody concentrations. b Two-dimensional iso-affinity kinetic plots of mRNA-encoded PGT121, VRC07, and their combination (PGT121 + VRC07). The table summarizes the equilibrium dissociation constants (KD), where lower values indicate higher binding affinity, along with the association (Ka) and dissociation constants (Kd). Diagonal dashed lines represent KD values. Reported KD values are the average of three experiments using an independent antibody dilution series.
