Fig. 7: Assessment of systemic and local toxicity of intravaginally delivered mRNA in female rhesus macaques.
a–c Blood samples were collected at baseline (0 h) and 24 h post-administration from three groups (n = 6 per group): negative control, SC-PGT121 + VRC07 IgM-tail, and SC-PGT121 + VRC07 aIgA. Heatmaps show log2 fold changes between pre- and post-treatment values. a Blood chemistry analysis (see Supplementary Fig. 6a for detailed data). b Peripheral blood mononuclear cell (PBMC) profiling by flow cytometry (see Supplementary Fig. 6b). c Cytokine and chemokine levels measured by multiplexed immunoassays (see Supplementary Fig. 10a). d Representative H&E-stained sections of female reproductive tissues from untreated (negative control) and mRNA-treated animals. The scale bar represents 100 µm. Additional images are shown in Supplementary Fig. 10b.
