Fig. 8: Systemic expression of mRNA-encoded IgA and IgM-tail antibodies via lipid nanoparticles (LNPs). | Nature Communications

Fig. 8: Systemic expression of mRNA-encoded IgA and IgM-tail antibodies via lipid nanoparticles (LNPs).

From: Intravaginal delivery of mRNA-encoded antibodies with enhanced breadth and potency for SHIV/HIV protection

Fig. 8: Systemic expression of mRNA-encoded IgA and IgM-tail antibodies via lipid nanoparticles (LNPs).

a Experimental design. For SC-PGT121 + VRC07 IgA or IgM-tail formulations, LNPs were diluted in saline at a 4:4:2 ratio. The LNP mixtures were delivered two times on days 0 and 2 via retro-orbital (RO) injection at 2 mg/kg dose (n = 5 per group). Serum samples were collected on day 3. Created in BioRender. Santangelo, P. (2025) https://BioRender.com/hj0jyqn. b Quantification of IgA and IgM-tail antibodies by ELISA. Data are presented as mean ± SD. c TZM-bl neutralization assays of mice serum samples against SHIV/HIV. Data are presented as mean ± SD. The 50% inhibitory concentrations (IC50) are summarized in the corresponding table. All neutralization assays were performed in duplicates and repeated at least twice in independent assays.

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