Fig. 2: Hierarchical clustering and principal component analysis of gene expression in different tissues during P. coatneyi infection.
From: Methylene blue treatment of fatal cerebral malaria and identification of potential blood biomarkers
a Heatmap display of the expression of 7403 most variable genes in all samples assayed by RNA-seq. The matrix of gene expression in TPM units was log1p transformed and scaled to z-score on the rows (genes). Hierarchical clustering of rows and columns was performed using complete linkage algorithm with Euclidean distance metric. b PCA of RNA-seq samples in brainstem, thalamus and cerebellum. c Schematic diagram comparing the macaque brain and human brain, indicating the brainstem (yellow), thalamus (red) and cerebellum (blue). Figure created in the Mind the Graph platform at www.mindthegraph.com, licensed under Creative Commons Attribution-ShareAlike 4.0 International License (CC BY-SA 4.0) https://creativecommons.org/licenses/by-sa/4.0/.
