Fig. 4: Results of differentially gene expression analysis. | Nature Communications

Fig. 4: Results of differentially gene expression analysis.

From: Methylene blue treatment of fatal cerebral malaria and identification of potential blood biomarkers

Fig. 4

a Gene expression comparisons between the experimental groups in different brain tissues. DEGs were selected based on adjusted p < 0.05 (two-sided Wald test in DESeq2 for estimating the false discovery rate) and >2-fold change in expression. b Venn diagram showing overlap of 574 genes modulated by infection (Pcoat+ MB− vs, Pcoat− MB−) and MB treatment (Pcoat+ MB+ vs. Pcoat+ MB−) in the brainstem. c Heatmap representation of 574 DEGs that were modulated by infection and normalized by MB treatment in the brainstem. Created in BioRender. Malleret, B. (2025) https://BioRender.com/lee54gw.

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