Fig. 2: GPR43 deficiency in eosinophils upregulates Th2 and Th17 responses in HDM-induced asthma. | Nature Communications

Fig. 2: GPR43 deficiency in eosinophils upregulates Th2 and Th17 responses in HDM-induced asthma.

From: GPR43 in eosinophils suppresses the emergence of pathogenic Siglec-Fhi neutrophils in allergic airway inflammation in mice

Fig. 2: GPR43 deficiency in eosinophils upregulates Th2 and Th17 responses in HDM-induced asthma.

a Cytokine levels in BALF. b Percentages of CD4 T cells expressing each transcription factor in asthmatic lungs. c Percentages of CD4 T cells producing each cytokine in asthmatic lungs. EpxCre/+ (n = 11), EpxCre/+Gpr43fl/fl (n = 12). Data in (a–c) were pooled from two independent experiments. d Cytokine levels in culture supernatants of asthmatic lung cells stimulated with anti-CD3 and anti-CD28. EpxCre/+ (n = 5), EpxCre/+Gpr43fl/fl (n = 6). Data in (d) are representative of three independent experiments. Data are presented as mean ± s.e.m. Statistical analysis was performed using an unpaired two-tailed Student’s t-test.

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