Table 2 Statistics of filament organization in 2-, 3-, and 4-filament full-length ASC bundles
From: Atomic mechanisms of full-length ASC-mediated inflammasome assembly
Total number of 2-filament full-length ASC bundles analyzed: 20 | |||
APYD–ACARD | 11 (55%) | Filaments of the same growth direction | 11 (55%) |
APYD–BCARD | 9 (45%) | Filaments of the opposite growth direction | 9 (45%) |
Total number of 3-filament full-length ASC bundles analyzed: 21 | |||
APYD–ACARD–APYD | 1 (5%) | Filaments that are one filament apart have same growth direction | 21 (100%) |
ACARD–APYD–ACARD | 13 (62%) | PYD in middle of 3-filament bundle | 18 (86%) |
APYD–BCARD–APYD | 2 (10%) | CARD in middle of 3-filament bundle | 3 (14%) |
ACARD–BPYD–ACARD | 5 (24%) | ||
Total number of 4-filament full-length ASC bundles analyzed: 18 | |||
APYD–ACARD–APYD–ACARD | 4 (22%) | Filaments that are one filament apart have same growth direction | 29 (81%) |
APYD–BCARD–APYD–BCARD | 8 (44%) | ||
APYD–BCARD–BPYD–BCARD | 1 (6%) | Filaments that are one filament apart have opposite growth directions | 7 (19%) |
APYD–ACARD–BPYD–ACARD | 5 (28%) | ||
