Fig. 2: Substrate scope for the Cu-catalyzed asymmetric formal [1 + 2 + 2]-cycloaddition.
From: Asymmetric formal [1 + 2 + 2]-cycloaddition of diazoamides with enamines and carbonyl compounds
![Fig. 2: Substrate scope for the Cu-catalyzed asymmetric formal [1 + 2 + 2]-cycloaddition.](http://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fs41467-025-65612-3/MediaObjects/41467_2025_65612_Fig2_HTML.png?as=webp)
Reaction conditions: 1 (0.10 mmol), 2 (0.15 mmol), 3 (0.10 mmol), Cu(CH3CN)4PF6 (1.8 mg, 5.0 mol%), L6 (2.9 mg, 6.0 mol%), DIPEA (1.8 μL, 10 mol%), and 4 Å MS (50 mg) in DCM (2.0 mL) at 30 °C. Yields are given in isolated yields. aThe reaction was conducted at 25 °C.
