Fig. 2: BASIC workflow. | Nature Communications

Fig. 2: BASIC workflow.

From: Integrating axis quantitative trait loci looks beyond cell types and offers insights into brain-related traits

Fig. 2

BASIC consists of three key steps, including 1) estimating cell-type weights from bulk eQTLs and sc-eQTLs; 2) using principal components of sc-eQTLs effects to cluster biologically similar cell types and cell states; 3) joint modeling axis-eQTLs and bk-eQTLs using a meta-regression model with principal components as covariates. The axis-QTLs can improve the discovery of risk genes for brain-related traits in downstream colocalization and TWAS analyses. This figure is created in BioRender. W, L. (2025) https://BioRender.com/r75v850.

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