Fig. 3: Comparison of significant eGenes identified by joint analysis of sc-eQTLs from Bryois et al and bk-eQTLs from MetaBrain data. | Nature Communications

Fig. 3: Comparison of significant eGenes identified by joint analysis of sc-eQTLs from Bryois et al and bk-eQTLs from MetaBrain data.

From: Integrating axis quantitative trait loci looks beyond cell types and offers insights into brain-related traits

Fig. 3: Comparison of significant eGenes identified by joint analysis of sc-eQTLs from Bryois et al and bk-eQTLs from MetaBrain data.

A, B compare the number of significant eSNPs and eGenes identified by five approaches: (i) using Bryois et al. only; (ii) mashr-sc (mashr applied to sc-eQTLs data), (iii) mashr-sc+bk (mashr applied to analyze sc-eQTLs and bk-eQTLs data), (iv) JOBS, and (v) BASIC. To facilitate the comparison of different methods, we use the Cauchy combination test to combine the p-values of different cell types or PCs. We also replicate significant eSNPs and eGenes in Fujita et al. C, D show the numbers of discovered and replicated eGenes and eSNPs based on axis-QTLs.

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