Fig. 9: A proposed model of the moonlighting function of MAT2A in wound healing.
From: A biomimetic senotherapy replenishing MAT2A promotes wound regeneration in preclinical models
Harmonious cellular communication and cooperation, as well as efficient transformation of cell phenotypes, are indispensable for wound regeneration. MAT2A downregulation mediated pericyte senescence in a moonlighting manner, which induced the infiltration of inflammatory macrophages in diabetic wounds. This discovery provides an saRNA-based strategy targeting senescent pericytes for wound healing. The diagram was created with BioRender.com.
