Fig. 1: Identification and taxonomic annotation of gmGUSs.
From: Gut microbial β-glucuronidases and their role in the microbiome-metabolite axis in colorectal cancer
a Flow chart of the pipeline used for identification of gmGUSs from Unigenes (n = 10,947,761), which employed a combination of 114 reference gmGUSs, three architectural domains of GUS enzymes (PF02836, PF02837 and PF00703), and seven GUS conserved residues. b Rarefaction curves showing the number of gmGUSs in healthy controls (n = 247), CRC patients (S0, SI/II and SIII/IV groups, n = 258), and total samples (n = 571) after 100 random samplings. c Taxonomic cladogram of 550 gmGUSs. The inner to outer circles represent the hierarchical taxonomic levels of kingdom, phylum, class, order, family, genus, and species, respectively. Different colors represent different phyla, and the bar chart indicates the number of annotated gmGUSs for respective species. The asterisks represent the top two orders with the highest gmGUS number. Source data are provided as a Source Data file.
