Fig. 4: Scope for pyridinium salts in C4- and C6-selective reductive dearomative hydroarylation. | Nature Communications

Fig. 4: Scope for pyridinium salts in C4- and C6-selective reductive dearomative hydroarylation.

From: Regioselective and site-divergent synthesis of tetrahydropyridines by controlled reductive-oxidative dearomative hydroarylation of pyridinium salts

Fig. 4: Scope for pyridinium salts in C4- and C6-selective reductive dearomative hydroarylation.

aReaction was conducted using 1 (0.5 mmol, 2.5 equiv), 2a (0.2 mmol, 1.0 equiv), [Co-2] (0.006 mmol, 3 mol%), TBPB (0.6 mmol, 3.0 equiv), Mn(OAc)2.4H2O (0.12 mmol, 0.6 equiv) and PhMe2SiH (4.0 equiv) in CH3CN (2.0 mL) at rt for 12 h. bReaction was conducted using 1 (0.4 mmol, 2.0 equiv), 2a (0.2 mmol, 1.0 equiv), A (0.4 mmol, 2.0 equiv) and PhMe2SiH (4.0 equiv) in CH3CN (2.0 mL) at rt for 12 h.

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