Fig. 3: Substrate scope of the d3-methylation using TT-OP-CD3.
From: Installation of d3-methyl group to drugs by continuous-flow solid-phase synthesis
Reaction conditions: 1 (0.5 mmol), TT-OP-CD3 (500 mg), K2CO3 (1.0 mmol), and MeCN (5 mL), rt, 12 h. Isolated yields. aTT-OP-CD3 (1000 mg), K2CO3 (2.0 mmol) were used.
