Table 2 Time and dose response probit analysis upon WHO adult bioassays with PM for the GAL4/UAS-Coeae6g progenies and the parental lines

From: Predictive chemoproteomics and functional validation reveal Coeae6g-mediated insecticide cross-resistance in the malaria vector Anopheles gambiae

Pirmiphos methyl resistance

GAL4/UAS- Coeae6g

LD50 or LT50 (95% CI)

Control Line

LD50 or LT50 (95% CI)

RR (95% CI)

An. gambiae LD50

2.4 (1.5–7.4)%

0.28 (0.25–0.32)%

8.6 (6.0–23.1)

An. coluzzi LT50

39.6 (34.2–45.3) min

5.2 (4.0–6.4) min

7.6 (6.4–8.8)

  1. Values were extracted from two to six biological replicates per exposure time point or PM dose, using 20–25 randomly picked female mosquitoes, from different batches. LD50 exposure dose required to cause 50% mortality, LT50 exposure time required to cause 50% mortality, RR resistance ratio (value defined as LD50 of GAL4/UAS- Coeae6g/LD50 Control or LT50 of GAL4/UAS- Coeae6g/LT50 Control), CI confidence intervals. Test values were calculated using Polo Plus 2.0.
Back to article page