Table 3 Time- response probit analysis upon WHO adult bioassays with different insecticides comparatively between GAL4/UAS-AncCoeae6g progeny and the A11 parental line

From: Predictive chemoproteomics and functional validation reveal Coeae6g-mediated insecticide cross-resistance in the malaria vector Anopheles gambiae

 

LT50 min (95% CI)

Insecticide (Dose)

GAL4/UAS- AncCoeae6g

A11

RR (95% CI)

Bendiocarb (0.10%)

20.4 (17.0–23.1)

9.4 (5.0–12.5)

2.2 (1.9–2.5)

Malathion (5%)

15.3 (13.1–17.4)

3.4 (2.9–3.8)

4.6 (3.8–5.5)

Permethrin (0.75%)

22.0 (16.4–27.7)

7.3 (5.1–10.4)

3.0 (2.2–4.1)

Deltamethrin (0.05%)

« 10 min

« 10 min

ND

  1. For each time point, at least 2 biological replicates of 20–25 randomly picked mosquitoes from separate batches each, were conducted per strain. LT50 exposure time required to cause 50% mortality, RR resistance ratio (values defined as LT50 of GAL4/UAS-AncCoeae6g divided by LT50 of A11 control), CI confidence intervals, ND not defined. Test values were calculated using Polo Plus 2.0.
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