Fig. 1: Structural insights into the portal of the central pocket (PCP) and allosteric modulation of P2X receptors.
From: Understanding interspecies drug response variations between human and rodent P2X7 receptors
a Side view comparison of the apo/resting state (dark slate blue, PDB ID: 6U9V) and open state (medium violet red, PDB ID: 6U9V) structures of the rat P2X7 (rP2X7) receptor. b Representation of the orthosteric site and three allosteric sites of P2X receptors. Allosteric site 1 (upper right) resides within the Inner Pocket of the Head Domain (IP-HD), while allosteric site 2 (lower right) is situated beneath the orthosteric site, encompassing the left flipper and low body domain (LF-LBD). c Illustration of allosteric site 3 located at the portal of the central pocket (PCP), depicting its structure from both sides and vertical views. Composition of the PCP and three sub-pockets: PCP1 (green dotted circle), PCP2 (blue dotted circle), and PCP3 (brown dotted circle), shown from top (d) and side (e, f) views. The PCP primarily consists of rigid β-sheets, including β2, β3, β4, β7, and β8.
