Fig. 2: Structure of Hsp90-FKBP51-PINK1 reveals the involvement of FKBP51 in PINK1 folding.
From: Molecular mechanism of PINK1 regulation by the Hsp90 machinery
a Composite cryo-EM map of the Hsp90-FKBP51-PINK1 complex in front and back view. b Atomic model of the Hsp90-FKBP51-PINK1 complex in cartoon representation. c The interface of Hsp90 lumen and PINK1 polypeptide, with Hsp90 lumen shown in surface representation and PINK1 shown in stick. d The detail view of the TPR domain of FKBP51 interacts with Hsp90. e The interface of the FK1 domain of FKBP51 and the PINK1 N-lobe is represented in cartoon mode, superimposed with the electron density. Hsp90A, cyan; Hsp90B, marine; PINK1, yellow; Cdc37, salmon.
