Fig. 3: Structure of Hsp90-PINK1 reveals a folded N-lobe of PINK1.
From: Molecular mechanism of PINK1 regulation by the Hsp90 machinery
a Composite cryo-EM map of the Hsp90-PINK1 complex in front and back view. Hsp90A, cyan; Hsp90B, marine; PINK1, yellow. b Atomic model of the Hsp90-PINK1 complex in cartoon representation. c Overall comparison of Hsp90-PINK1 complex, Hsp90- Cdc37-PINK1 complex and Hsp90-FKBP51-PINK1 complex in front view and back view. For the Hsp90-PINK1 complex, Hsp90A is colored in cyan, Hsp90B is colored in marine, and PINK1 is colored in yellow. Hsp90-Cdc37-PINK1 complex is colored in orange, and Hsp90-FKBP51-PINK1 complex is colored in gray. d The structural comparison of PINK1 C-lobe. e The superimposed of PINK1 N-lobe and Cdc37 Middle Domain (Cdc37-MD).
