Fig. 6: Representative examples for the synthesis of β-radiofluoroamines. | Nature Communications

Fig. 6: Representative examples for the synthesis of β-radiofluoroamines.

From: Iron-catalyzed three-component amino(radio)fluorination of alkenes to unprotected β-(radio)fluoroamines

Fig. 6

Standard radiofluorination reaction conditions involved the addition of [18F]TMAF·HFIP and Et3N (0.2 equiv.) in an 8:1 DCM: HFIP solution (0.4 mL) to a solid mixture containing alkene (0.025 mmol), hydroxylamine reagent V (2.5 equiv.), FePc (0.1 equiv.), and Et2NH·HCl (0.25–0.5 equiv.) at 30 °C. The reaction was allowed to proceed for 30 min. Amine products were characterized and quantified as their Boc-protected derivatives by radio-TLC and/or analytic radio-HPLC. Radiochemical conversions (RCCs) determined for crude reaction mixtures are shown. A decay-corrected (d.c.) radiochemical yield (RCY) is provided for substrate [18F]2a.

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