Fig. 3: The structure of the TkoTpt1/DNA/NAD+ complex.
From: Crystal structures and snapshots along Tpt1-catalyzed phosphate transfer from nucleic acid to NAD+
a Overall folding of the TkoTpt1/DNA/NAD+ complex. The N-lobe and NAD+-lobe are shown as cartoon in yellow and green, respectively. b 2Fo-Fc electron density maps of the bound DNA molecule, NAD+, and SO42-. c The detailed interactions between TkoTpt1 and NAD+ (top panel), DNA (middle panel), or SO42- (bottom panel). The Hydrogen-bond interactions are indicated by black dashed lines. d Superposition showing the large conformational change between the N-lobe and NAD+-lobe in the TkoTpt1/DNA/NAD+ complex and the unliganded structure, which is colored in blue.
