Fig. 3: Non-targeted discovery of plaque-associated lipids in 5xFAD mice. | Nature Communications

Fig. 3: Non-targeted discovery of plaque-associated lipids in 5xFAD mice.

From: Multimodal mass spectrometry imaging for plaque- and region-specific neurolipidomics in Alzheimer’s disease mouse models

Fig. 3

a Representative ion image at m/z 1179.73, representative of all measurements from 5xFAD animals. b Extraction of plaque-localized pixels from the ion image. c Extraction of control pixels from the same ion image. d Volcano plot highlighting discovery of plaque enriched and depleted lipids. Data were compared with a two-sided t-test (no FDR correction). e Average difference mass spectrum highlights discovered enriched and depleted lipids. f A zoomed-in region of the difference plot from m/z 1100 to 1600 is included to highlight ganglioside differences. Measurements in all panels were obtained from n = 3 animals, two sections per animal. Source data are provided as a Source data file.

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