Fig. 6: Integrated MALDI and spatial transcriptomics. | Nature Communications

Fig. 6: Integrated MALDI and spatial transcriptomics.

From: Multimodal mass spectrometry imaging for plaque- and region-specific neurolipidomics in Alzheimer’s disease mouse models

Fig. 6

a Pathways for simple ganglioside synthesis and degradation. b Volcano plot of genes involved in ganglioside synthesis and degradation in 5xFAD mice from a publicly available dataset40. c Volcano plot of ganglioside genes in APPNL-G-F mice from a publicly available dataset3. d Coenrichment (log2FC gene × log2FC lipid) by region. All possible lipid gene pairs are considered and are plotted in descending order. e Corresponding coenrichment in APPNL-G-F mice. Data in c, d were compared with a two-sided t-test (no FDR correction). Source data are provided as a Source data file.

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