Fig. 7: MALDI TIMS MSI of ganglioside isomers. | Nature Communications

Fig. 7: MALDI TIMS MSI of ganglioside isomers.

From: Multimodal mass spectrometry imaging for plaque- and region-specific neurolipidomics in Alzheimer’s disease mouse models

Fig. 7

a Extracted ion mobilogram (EIM) at m/z 1544.87 shows the TIMS-enabled separation of GM1b(36:1) and GM1a(36:1) in wild type and 5xFAD mice. b Ion images are shown for mobility-selected GM1b(36:1) in blue, GM1a(36:1) in red, and a merged image of both. In c the EIM at m/z 1572.90 shows separation of the a and b isomers of a longer-chain version of GM1, GM1(38:1) with corresponding ion images in (d).

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