Fig. 9: MF-8 blocks CCKBR mediated fear memory.
From: Discovery of a β-arrestin-biased CCKBR agonist that blocks CCKBR-dependent long-term potentiation
A Diagram of MF-8 treatment on the day before tone-to-tone pair training, tone-to-tone pair training (day 1–3, f1 = 1k Hz, f2 = 4k Hz), baseline tests and conditioning of footshock with f2 (day 4), and freezing tests (day 5). B Bar charts show freezing percentages of the C57 mice with saline (gray, N = 12 mice) and MF-8 (red, N = 15 mice) injection. One-way ANOVA with Tukey’s multiple comparisons tests were used: ****p < 0.0001; **P < 0.01; NS, not significant. The exact P-values were shown in the source data.
