Fig. 2: Identification of genetic mutations and frequencies within OriCol™ samples. | Nature Communications

Fig. 2: Identification of genetic mutations and frequencies within OriCol™ samples.

From: Hologenomic analysis of rectal mucus sampling for detection of adenomatous polyps and colorectal cancer

Fig. 2: Identification of genetic mutations and frequencies within OriCol™ samples.

a OncoPrint of CRC cases (n = 78) in the ecNGS cohort across the 25 genes which remained after filtering. The top horizontal bar is per-participant mutation burden and the right vertical bar is per-gene mutation count. b Hierarchically clustered heatmap of per-gene, per-participant maximum VAFs across the 161-participant ecNGS cohort for 25 genes that remained after filtering (control n = 47; CRC n = 78; early-stage polyps n = 19; late-stage polyps n = 7; small bowel cancer n = 1; no CRC n = 9). The bars along the bottom of the heatmap denote clinical category, pathology site, and cancer stage. E-Polyps + , Early-stage polyps; L-Polyps + , Late-stage polyps; C+ Other, Small bowel cancer; No CRC, Not diagnosed with CRC and not assessed by gold-standard examinations.

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