Fig. 3: YF-ZIK induced immunogenicity in macaques and protection of mice from lethal ZIKV challenge by passively transferred serum from immunized NHPs. | Nature Communications

Fig. 3: YF-ZIK induced immunogenicity in macaques and protection of mice from lethal ZIKV challenge by passively transferred serum from immunized NHPs.

From: Immunological and transcriptomic profile of chimeric live-attenuated Zika vaccine linked to protection in non-human primates

Fig. 3: YF-ZIK induced immunogenicity in macaques and protection of mice from lethal ZIKV challenge by passively transferred serum from immunized NHPs.

a Kinetics of ZIKV-specific SNT90 NAbs in macaques. LLOD, the lower limit of detection. b Total ZIKV-specific IgG, NAbs (left y-axis) and the respective ratio (right y-axis) at different timepoints after vaccination. c Kinetics of Activation-induced cytidine deaminase (AICDA) transcript levels in circulating PBMCs of YF-ZIK-immunized macaques. d, e Passive serum transfer study scheme (d) and survival rate after ZIKV MR766 challenge (e). AG129 mice received a single dose of 450 µl of NHPs serum pool from either YF-ZIK-immunized macaques or sham-immunized macaques by intraperitoneal (i.p) injection. Mice were challenged 24 h later by i.p. injection with 10 PFU of ZIKV MR766 (n = 9–10 from two independent experiments). Differences in Kaplan–Meier survival curves (e) were assessed using the two-sided Log-rank (Mantel-Cox) test. d was created in BioRender. Ma, J. (2025) https://BioRender.com/jebjnt0.

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