Fig. 5: MTS105 induced more intratumoral CD8 T cell precursor and terminally differentiated memory subsets. | Nature Communications

Fig. 5: MTS105 induced more intratumoral CD8 T cell precursor and terminally differentiated memory subsets.

From: Organ-specific delivery of an mRNA-encoded bispecific T cell engager targeting glypican-3 in hepatocellular carcinoma

Fig. 5

A UMAP showing the tumor-infiltrating immune cells and non-immune cells from mice (n = 3 mice per group) treated with Tris vehicle control, MTS105 (0.5 μg/mouse) or ERY974 (1 mg/kg). B Cell ratio and cell numbers of clusters identified in (A). C UMAP showing T cell clusters in tumors treated with Tris, MTS105, and ERY974. D Comparison of the proportions of five T subsets, and E comparison of T cell activation score in Tris, MTS105, and ERY974 groups. F UMAP showing CD8 T cell clusters in tumors treated with Tris, MTS105 and ERY974. G Comparison of the proportions of 12 CD8 T clusters in Tris, MTS105 and ERY974 groups. H Comparison of the cell ratio of C2, C4, C5 subsets in Tris and MTS105-treated tumors. I Differentiation trajectory of CD8 T cells. Color scale indicates the ordering of cells in pseudotime. J Heat map of pseudotime-correlated genes. Color scale indicates gene expression level. K B2m and Ccl5 expression in pseudotime trajectory analysis. In the box plot, the lower and upper edges represent the first (Q1, 25%) and third (Q3, 75%) quartiles, respectively, with the central line indicating the median (Q2, 50%). Statistical analysis was performed using two-sided Wilcoxon rank-sum tests.

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