Fig. 5: Prognostic models for CAD adverse outcomes.
From: DNA methylation predicts adverse outcomes of coronary artery disease
a ROC curves of the prognostic models of death as constructed based on the discovery set. CG refers to the selected 10 DMPs for model construction. The Ensemble model is composed of 10 DMPs + sex + age + FIB + HDLC + LVEF, and the clinical model is composed of sex + age + FIB + HDLC + LVEF. b Prediction scores when applying the prognostic models of death to the discovery set, with patients categorized by different clinical outcomes (nno adverse outcome = 160, nRevascularization = 34, nStroke = 27, nMI = 26, nDeath = 158). c Kaplan-Meier curves when applying the Ensemble model to the validation set. Patients having all the modeling features were considered. d Prediction scores in the validation set, with patients categorized by clinical outcomes (nSurvival = 503, nDeath = 25). b, d In the boxplot of panels, hinges indicate the 25th, 50th, and 75th percentiles, whiskers indicate 1.5× interquartile ranges. The two-sided P-values were calculated by Kruskal-Wallis test. FIB fibrinogen, HDLC high-density lipoprotein cholesterol, LVEF left ventricular ejection fraction.
